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KMID : 0387420180290030145
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Korean Society of Oriental Neuropsychiatry
2018 Volume.29 No. 3 p.145 ~ p.163
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A Study on Homogeneity Analysis of the Guipi Decoction for Treatment of Insomnia Disorder-Focusing on Randomized Controlled Clinical Trials in CNKI
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Kim Dong-Hee
Sakong Jong-Won
Kang Chang-Wan
Lee Sang-Hyup
Ha Ji-Won
Kim Bo-Kyung
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Abstract
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Objectives: The study was designed to provide clinical evidence of homogeneity in analysis of the herb-al medicine, Guipi decoction in treating insomnia, using a t-test of randomized controlled trials (RCTs).
Methods: This study included RCTs that verified homogeneity of Guipi decoction in treating insomnia. Literature studies of CNKI (Chinese National Knowledge Infrastructure Database) were performed. The basic components group was made to the Guipi decoction of the Yixuerumen?s text. The excluded group was created with the number of herbs excluded from the basic components group. T-test per-formed that the effective rate in the basic components group and excluded groups.
Results: The basic components of Guipi decoction contain Atractylodis Rhizoma Alba, Poria Sclerotium (Poria Sclerotium Cum Pini Radix), Polygalae Radix, Astragali Radix, Zizyphi Semen, Angelicae Gigantis Radix, Aucklandiae Radix, Glycyrrhiza uralensis Fischer, Ginseng Radix (Codonopsis Pilosulae Radix), Longanae Arillus. Herbs excluded from the basic components group were Longanae Arillus, Ginseng Radix (Codonopsis Pilosulae Radix), Glycyrrhiza uralensis Fischer and herbs added to the basic compo-nents group were Polygonum multiflorum Thunberg, Schisandrae Fructus, Salviae Militiorrhizae Radix, Paeoniae Radix Alba (in order from the most used to the least). T-test revealed the effective rate in the basic components group was not statistically significant compared to the excluded groups (p=0.161/p=0.162/p=0.103).
Conclusions: Effectiveness in treatment of basic components of Guipi decoction and excluded groups were revealed to be homogeneous in treating insomnia. As the number of herbs in the basic compo-nents group decreased, mean value in effectiveness of treatment also decreased consequentially. However, there were no statistical significances.
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KEYWORD
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Insomnia disorder, Guipi Decoction, Homogeneity, Systematic review
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